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kn93  (MedChemExpress)


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    Structured Review

    MedChemExpress kn93
    Kn93, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 133 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/kn+93/KN-93/pm42421049-121-34-38
    Average 96 stars, based on 133 article reviews
    kn93 - by Bioz Stars, 2026-10
    96/100 stars

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    Related Articles

    Injection:

    Article Title: Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis
    Article Snippet: For D. melanogaster , JH III bisepoxide (Toronto Research Chemicals) was administered at the doses of 0.1 μg/larva and 0.5/adult. .. In pharmacological experiments, the early fourth instar nymphs and previtellogenic adults of L. migratoria were injected with suramin (KKL MED; 30 μg, 150 μg), SU6668 (Selleck; 0.6 μg, 3 μg), genistein (MCE; 1.2 μg, 6 μg), U73122 (MCE; 2 μg, 10 μg), KN‐93 (MCE; 0.5 μg, 10 μg), CCL (Selleck; 1 μg, 5 μg), flunarizine (Selleck; 10 μg, 50 μg), Felodipine (TOPSCIENCE; 1 μg, 5 μg), Cav2.2 blocker 1 (TOPSCIENCE; 2 μg, 10 μg), ω‐Agatoxin TK (MCE; 0.25 μg,1 μg) and SNX‐482 (MCE; 0.25 μg, 1 μg), followed by JH or DMSO treatment for 30 min. ..

    Article Title: Low-Intensity Pulsed Ultrasound Alleviation of LPS-Induced Depression-Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation.
    Article Snippet: .. KN- 93 (HY- 15465, MCE), a CaMKII inhibitor, was diluted in PBS to a concentration of 2.5 mg/mL and administered at a dose of 1 mg/kg/day via intraperitoneal injection, starting 30 min after LPS administration, for a total of 7 days. ..

    Article Title: Low‐Intensity Pulsed Ultrasound Alleviation of LPS‐Induced Depression‐Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation
    Article Snippet: .. KN‐93 (HY‐15465, MCE), a CaMKII inhibitor, was diluted in PBS to a concentration of 2.5 mg/mL and administered at a dose of 1 mg/kg/day via intraperitoneal injection, starting 30 min after LPS administration, for a total of 7 days. ..

    Cell Culture:

    Article Title: Tongmai Yishen Formula alleviates post-stroke depression by restoring neuronal homeostasis in the lateral habenula via the ITPKA signaling pathway
    Article Snippet: .. Cells were cultured in glucose-free medium (PM150283, Procell, China) at 37°C, 1% O2, and 5% CO2 in a hypoxic incubator for 2 h. After 12h, SH-SY5Y-specific medium was reintroduced in the presence of corticosterone (500μmol/L) (Yang et al., 2021) (HY-B1618, MCE, USA) for continued culture, thereby inducing the SH-SY5Y post-stroke depression cell model. ITPKA was inhibited using BAMB-4 (ITPKA-IN-C14) (35 μmol/L) (HY-16694, MCE, USA) (Schröder et al., 2013), βCaMKII was blocked using KN-93 (6 μmol/L) (HY-15465, MCE, USA) (Tombes et al., 1995), and TMYSF serum (10%) was used for intervention. ..

    Concentration Assay:

    Article Title: Low-Intensity Pulsed Ultrasound Alleviation of LPS-Induced Depression-Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation.
    Article Snippet: .. KN- 93 (HY- 15465, MCE), a CaMKII inhibitor, was diluted in PBS to a concentration of 2.5 mg/mL and administered at a dose of 1 mg/kg/day via intraperitoneal injection, starting 30 min after LPS administration, for a total of 7 days. ..

    Article Title: Low‐Intensity Pulsed Ultrasound Alleviation of LPS‐Induced Depression‐Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation
    Article Snippet: .. KN‐93 (HY‐15465, MCE), a CaMKII inhibitor, was diluted in PBS to a concentration of 2.5 mg/mL and administered at a dose of 1 mg/kg/day via intraperitoneal injection, starting 30 min after LPS administration, for a total of 7 days. ..

    Incubation:

    Article Title: Rutin triggers IRE1-mediated GSDMD-dependent pyroptosis in macrophages to suppress systemic Salmonella infection.
    Article Snippet: .. The intervention reagents Dimethyl fumarate (DMF, MCE, HY-17363), 4l8c (MCE, HY-19707), KN-93 (MCE, HY-15465) and Toyocamycin (MCE, HY-103248) are then co-incubated with RT and the cells are incubated for a further six hours. ..



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    Regulation of suc‐H3 K14 and suc‐H3 K23 by the GPCR‐RTK‐PLC‐PKC cascade. (A) Effect of GPCR (Suramin), RTK (SU6668/genistein), PLC (U73122), CaMKII <t>(KN‐93),</t> and PKC (CCL) inhibitors on JH‐induced suc‐H3 K14 in the fourth instar nymphs. (B) Effect of Ca 2+ channel blockers (felodipine, L‐type; flunarizine, T‐type; cav2.2, N‐type; ω‐Agatoxin TK, P/Q‐type; and SNX‐482, R‐type) on suc‐H3 K14 . (C) Knockdown efficiency of PKC isoforms in the fat body of fourth instar nymphs. ** , p < 0.01; n = 3. (D) Effect of PKC isoform knockdown on suc‐H3 K14 . (E, F) Effect of GPCR, RTK, PLC, CaMKII, and PKC inhibitors ( E ) and Ca 2+ channel blockers ( F ) on JH‐induced suc‐H3 K23 in the adult females. (G) Knockdown efficiency of PKC isoforms in the adult females. ** , p < 0.01; n = 3). (H) Effect of PKC isoform knockdown on suc‐H3 K23 in the adult females.
    Kn 93, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    MedChemExpress medchemexpress hy 15465 kn
    Regulation of suc‐H3 K14 and suc‐H3 K23 by the GPCR‐RTK‐PLC‐PKC cascade. (A) Effect of GPCR (Suramin), RTK (SU6668/genistein), PLC (U73122), CaMKII <t>(KN‐93),</t> and PKC (CCL) inhibitors on JH‐induced suc‐H3 K14 in the fourth instar nymphs. (B) Effect of Ca 2+ channel blockers (felodipine, L‐type; flunarizine, T‐type; cav2.2, N‐type; ω‐Agatoxin TK, P/Q‐type; and SNX‐482, R‐type) on suc‐H3 K14 . (C) Knockdown efficiency of PKC isoforms in the fat body of fourth instar nymphs. ** , p < 0.01; n = 3. (D) Effect of PKC isoform knockdown on suc‐H3 K14 . (E, F) Effect of GPCR, RTK, PLC, CaMKII, and PKC inhibitors ( E ) and Ca 2+ channel blockers ( F ) on JH‐induced suc‐H3 K23 in the adult females. (G) Knockdown efficiency of PKC isoforms in the adult females. ** , p < 0.01; n = 3). (H) Effect of PKC isoform knockdown on suc‐H3 K23 in the adult females.
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    kn93  (Tocris)
    95
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    Regulation of suc‐H3 K14 and suc‐H3 K23 by the GPCR‐RTK‐PLC‐PKC cascade. (A) Effect of GPCR (Suramin), RTK (SU6668/genistein), PLC (U73122), CaMKII <t>(KN‐93),</t> and PKC (CCL) inhibitors on JH‐induced suc‐H3 K14 in the fourth instar nymphs. (B) Effect of Ca 2+ channel blockers (felodipine, L‐type; flunarizine, T‐type; cav2.2, N‐type; ω‐Agatoxin TK, P/Q‐type; and SNX‐482, R‐type) on suc‐H3 K14 . (C) Knockdown efficiency of PKC isoforms in the fat body of fourth instar nymphs. ** , p < 0.01; n = 3. (D) Effect of PKC isoform knockdown on suc‐H3 K14 . (E, F) Effect of GPCR, RTK, PLC, CaMKII, and PKC inhibitors ( E ) and Ca 2+ channel blockers ( F ) on JH‐induced suc‐H3 K23 in the adult females. (G) Knockdown efficiency of PKC isoforms in the adult females. ** , p < 0.01; n = 3). (H) Effect of PKC isoform knockdown on suc‐H3 K23 in the adult females.
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    Selleck Chemicals kn
    Regulation of suc‐H3 K14 and suc‐H3 K23 by the GPCR‐RTK‐PLC‐PKC cascade. (A) Effect of GPCR (Suramin), RTK (SU6668/genistein), PLC (U73122), CaMKII <t>(KN‐93),</t> and PKC (CCL) inhibitors on JH‐induced suc‐H3 K14 in the fourth instar nymphs. (B) Effect of Ca 2+ channel blockers (felodipine, L‐type; flunarizine, T‐type; cav2.2, N‐type; ω‐Agatoxin TK, P/Q‐type; and SNX‐482, R‐type) on suc‐H3 K14 . (C) Knockdown efficiency of PKC isoforms in the fat body of fourth instar nymphs. ** , p < 0.01; n = 3. (D) Effect of PKC isoform knockdown on suc‐H3 K14 . (E, F) Effect of GPCR, RTK, PLC, CaMKII, and PKC inhibitors ( E ) and Ca 2+ channel blockers ( F ) on JH‐induced suc‐H3 K23 in the adult females. (G) Knockdown efficiency of PKC isoforms in the adult females. ** , p < 0.01; n = 3). (H) Effect of PKC isoform knockdown on suc‐H3 K23 in the adult females.
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    Selleck Chemicals kn93
    Regulation of suc‐H3 K14 and suc‐H3 K23 by the GPCR‐RTK‐PLC‐PKC cascade. (A) Effect of GPCR (Suramin), RTK (SU6668/genistein), PLC (U73122), CaMKII <t>(KN‐93),</t> and PKC (CCL) inhibitors on JH‐induced suc‐H3 K14 in the fourth instar nymphs. (B) Effect of Ca 2+ channel blockers (felodipine, L‐type; flunarizine, T‐type; cav2.2, N‐type; ω‐Agatoxin TK, P/Q‐type; and SNX‐482, R‐type) on suc‐H3 K14 . (C) Knockdown efficiency of PKC isoforms in the fat body of fourth instar nymphs. ** , p < 0.01; n = 3. (D) Effect of PKC isoform knockdown on suc‐H3 K14 . (E, F) Effect of GPCR, RTK, PLC, CaMKII, and PKC inhibitors ( E ) and Ca 2+ channel blockers ( F ) on JH‐induced suc‐H3 K23 in the adult females. (G) Knockdown efficiency of PKC isoforms in the adult females. ** , p < 0.01; n = 3). (H) Effect of PKC isoform knockdown on suc‐H3 K23 in the adult females.
    Kn93, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Regulation of suc‐H3 K14 and suc‐H3 K23 by the GPCR‐RTK‐PLC‐PKC cascade. (A) Effect of GPCR (Suramin), RTK (SU6668/genistein), PLC (U73122), CaMKII (KN‐93), and PKC (CCL) inhibitors on JH‐induced suc‐H3 K14 in the fourth instar nymphs. (B) Effect of Ca 2+ channel blockers (felodipine, L‐type; flunarizine, T‐type; cav2.2, N‐type; ω‐Agatoxin TK, P/Q‐type; and SNX‐482, R‐type) on suc‐H3 K14 . (C) Knockdown efficiency of PKC isoforms in the fat body of fourth instar nymphs. ** , p < 0.01; n = 3. (D) Effect of PKC isoform knockdown on suc‐H3 K14 . (E, F) Effect of GPCR, RTK, PLC, CaMKII, and PKC inhibitors ( E ) and Ca 2+ channel blockers ( F ) on JH‐induced suc‐H3 K23 in the adult females. (G) Knockdown efficiency of PKC isoforms in the adult females. ** , p < 0.01; n = 3). (H) Effect of PKC isoform knockdown on suc‐H3 K23 in the adult females.

    Journal: Advanced Science

    Article Title: Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

    doi: 10.1002/advs.75624

    Figure Lengend Snippet: Regulation of suc‐H3 K14 and suc‐H3 K23 by the GPCR‐RTK‐PLC‐PKC cascade. (A) Effect of GPCR (Suramin), RTK (SU6668/genistein), PLC (U73122), CaMKII (KN‐93), and PKC (CCL) inhibitors on JH‐induced suc‐H3 K14 in the fourth instar nymphs. (B) Effect of Ca 2+ channel blockers (felodipine, L‐type; flunarizine, T‐type; cav2.2, N‐type; ω‐Agatoxin TK, P/Q‐type; and SNX‐482, R‐type) on suc‐H3 K14 . (C) Knockdown efficiency of PKC isoforms in the fat body of fourth instar nymphs. ** , p < 0.01; n = 3. (D) Effect of PKC isoform knockdown on suc‐H3 K14 . (E, F) Effect of GPCR, RTK, PLC, CaMKII, and PKC inhibitors ( E ) and Ca 2+ channel blockers ( F ) on JH‐induced suc‐H3 K23 in the adult females. (G) Knockdown efficiency of PKC isoforms in the adult females. ** , p < 0.01; n = 3). (H) Effect of PKC isoform knockdown on suc‐H3 K23 in the adult females.

    Article Snippet: In pharmacological experiments, the early fourth instar nymphs and previtellogenic adults of L. migratoria were injected with suramin (KKL MED; 30 μg, 150 μg), SU6668 (Selleck; 0.6 μg, 3 μg), genistein (MCE; 1.2 μg, 6 μg), U73122 (MCE; 2 μg, 10 μg), KN‐93 (MCE; 0.5 μg, 10 μg), CCL (Selleck; 1 μg, 5 μg), flunarizine (Selleck; 10 μg, 50 μg), Felodipine (TOPSCIENCE; 1 μg, 5 μg), Cav2.2 blocker 1 (TOPSCIENCE; 2 μg, 10 μg), ω‐Agatoxin TK (MCE; 0.25 μg,1 μg) and SNX‐482 (MCE; 0.25 μg, 1 μg), followed by JH or DMSO treatment for 30 min.

    Techniques: Knockdown